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Mycobacterium tuberculosis CarD, an essential global …

04/07/2018  · CarD is an essential global transcription regulator from Mycobacterium tuberculosis (Mtb) that binds RNA polymerase and activates transcription by stabilizing the transcription initiation complex.

CarD contributes to diverse gene expression outcomes …

02/07/2019  · Here, we find that CarD serves as a global transcription regulator in Mtb that can either activate or repress gene expression, depending on the intrinsic properties of a given promoter. These studies elucidate paradigms of transcription regulation in the many bacteria phyla that encode homologs of CarD.

CarD and RbpA modify the kinetics of initial transcription …

26/07/2019  · These experiments indicated that CarD serves to activate transcription by increasing the rate of DNA opening and slowing the rate of bubble collapse, thereby enhancing RP o stability . RbpA, on the other hand, activates transcription by mainly increasing the rate of DNA opening, with little effect on the rate of closing ( 15 , 21 , 25 ).

Structural basis of transcriptional activation by the …

Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7 Graphical abstract Highlights d Structure of an M. tuberculosis transcription initiation … Like CarD and RbpA, the WhiB family of TFs are absent in Eco but critical for the Mtb lifestyle. WhiBs were initially discovered in antibiotic …

Structural basis of transcriptional activation by the …

Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7 Mol Cell . 2021 Jun 15;S1097-2765(21)00401-9. doi: 10.1016/j.molcel.2021.05.017.

Contribution of MINCLE-SYK Signaling to Activation of …

Trehalose-6,6-dimycolate (TDM), the mycobacterial cord factor, is an abundant cell wall glycolipid and major virulence factor of Mycobacterium tuberculosis. Its synthetic analog trehalose-6,6-dibehenate (TDB) is a new adjuvant currently in phase I clinical trials. In rodents, the C-type lectin receptors Mincle and Mcl bind TDB/TDM and activate …

Chapter 2 Transmission and Pathogenesis of Tuberculosis

Mycobacterium tuberculosis (M. tuberculosis) (Figure 2.1). M. tuberculosis. and seven very closely related mycobacterial species (M. bovis, M. africanum, M. microti, M. caprae, M. pinnipedii, M. canetti. and . M. mungi) together comprise what is known as the . M. tuberculosis. complex. Most, but not all, of these species have been found to cause disease in humans. In …

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What is the physiology of Mycobacterium tuberculosis?

Mycobacterium tuberculosis. The physiology of M. tuberculosis is highly aerobic and requires high levels of oxygen. Primarily a pathogen of the mammalian respiratory system, it infects the lungs. The most frequently used diagnostic methods for tuberculosis are the tuberculin skin test, acid-fast stain, culture, and polymerase chain reaction.

What are the reservoirs of Mycoplasma tuberculosis?

Humans are the only known reservoirs of M. tuberculosis. A misconception is that M. tuberculosis can be spread by shaking hands, making contact with toilet seats, sharing food or drink, sharing toothbrushes, or kissing.

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Go to New ATM Card Activation- In the current page, you will find various ATM card services like “Block ATM card”, “ATM pin generation” etc. Here you need to click on the option “New ATM card activation”. 5. Select your account- In the “New ATM card activation” page, you will find information related to your various accounts.

Is Mycobacterium tuberculosis Gram positive or negative?

Mycobacterium tuberculosis. First discovered in 1882 by Robert Koch, M. tuberculosis has an unusual, waxy coating on its cell surface primarily due to the presence of mycolic acid. This coating makes the cells impervious to Gram staining, and as a result, M. tuberculosis can appear either Gram-negative or Gram-positive.

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